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New
Products from Enzo Life Sciences
October
2009
View all the New Products
on our Website
 NEW Antibodies Section
Nuclear-ID™ Green
Cell Cycle Kit for flow cytometry
Useful for staining cells based upon their DNA content. The stain can be
applied to live, detergent-permeabilized or fixed cells (wide range of
cell densities, even at 106 cells/ml) to quantify their
distribution in three major phases of the cell cycle (G0/G1,
S and G2/M). The stain can also be used to measure apoptotic
cells in the sub-G1 phase.
Figure:
Consistent results over a wide range of cell densities.
Related Product: Nuclear-ID™ Red Cell Cycle
Kit (GFP-Certified™) for flow cytometry
FTO (mouse)
(IntraCellular) ELISA Kit
For the quantitative determination of intracellular FTO in mouse cell
lysates. In the mouse brain, FTO is highly expressed in hypothalamic
nuclei that control eating behavior.
Related Product: FTO (human)
(IntraCellular) ELISA Kit
α-Synuclein
(human) (rec.) -
A major component of Parkinson’s disease aggregates
Expressed in E. coli.
Wild-type or mutant α-synucleins are associated with familial Parkinson’s
disease. They are suitable for functional and aggregation studies.
Related Products: α-Synuclein (human) (rec.)
(A53T Mutant) / α-Synuclein (human) (rec.)
(A30P Mutant) / α-Synuclein (human) (rec.)
(E46K Mutant) / α-Synuclein, pAb /
β -Synuclein, pAb
/ α-Synuclein (human), mAb
(15G7) / α-Synuclein (human), mAb
(5C2)
Figure:
De-waxed section of human brain temporal cortex showing α-synuclein
immunoreactivity in Lewy bodies using α-Synuclein, pAb.
Micrograph provided
courtesy of Dr J.-P. Brion, Université Libre de Bruxelles, Belgium.
Linear
Polyubiquitin Chains - New tools for structural and functional studies
Linear polyubiquitin chains, in which the C-terminal glycine of one
ubiquitin is conjugated to the N-terminal methionine of an adjacent
ubiquitin, have been shown to be assembled in vitro. Ubiquitin binding domains
(UBDs) with a preference for linear polyubiquitin have been identified,
and a role for linear polyubiquitin in NF-κB pathway activation has been
reported. Such findings suggest an importance for linear chains in
cellular processes in addition to those that are lysine-based and
isopeptide-linked.
Di-ubiquitin (Ub2)
(linear)
Tri-ubiquitin (Ub3)
(linear)
Tetra-ubiquitin (Ub4)
(linear)
Penta-ubiquitin (Ub5)
(linear)
Hexa-ubiquitin (Ub6)
(linear)
Hepta-ubiquitin (Ub7)
(linear)
Octa-ubiquitin (Ub8)
(linear)
Nona-ubiquitin (Ub9)
(linear)
Deca-ubiquitin (Ub10)
(linear)
Undeca-ubiquitin (Ub11)
(linear)
Bilobalide
- Neuroprotective
and neurotrophic agent
Suppresses hypoxia-induced membrane breakdown in the brain. Inhibits
serum deprivation and drug-induced neuronal apoptosis.
LIT: J. Klein et al.; Brain Res. 755, 347 (1997) •
D. Janssens et al.; Biochem. Pharmacol. 58, 109 (1999)
R(-)-Deprenyl .
HCl - Neuroprotective
and neurotrophic agent
Inhibits apoptosis induced by kainic acid, hypoxia and growth factor withdrawal.
LIT: L. Xu et. al.; Biochem. Pharmacol. 58, 1183 (1999)
UPF1035
and UPF1069 - PARP-2 specific inhibitors
PARP-2 has been implicated in multiple DNA repair pathways. It seems to
be involved in later steps of the DNA repair processes and has also been
shown to be involved in diverse processes such as spermatogenesis,
adipogenesis, and T cell development.
LIT: R. Pellicciari, et al.; ChemMedChem 3, 914 (2008) • F. Moroni, et al.; Br. J. Pharmacol. 157, 854 (2009)
Alternariol
monomethyl ether
- A mycotoxin contaminant of fruit and cereal products
Exhibits antifungal and phytotoxic activity. Has also been shown to
possess DNA strand-breaking activity and inhibits the activity of
topoisomerase IIα in mammalian cell models.
LIT: H. Raistrick, et al.; Biochem. J. 55,
421 (1953) • E. Pfeiffer, et al.; Mol. Nutr. Food Res. 51, 307 (2007) • M. Fehr et al.; Mol. Nutr. Food Res. 53, 441 (2009)
Related Products: Alternariol
/ Altenusin
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