Colon cancer update
By Tom Vendelbo: 10.01.07 in Drug discovery research
Our partner, Bethyl Laboratories, offers an extensive selection of antibodies to proteins involved in the DNA repari process. Here is the most recent product update in this area.
Quote from January Product Update:
Mutations in the MSH6 gene have been reported in about 10 percent of hereditary nonpolyposis colon cancer (HNPCC) families that have an identified gene mutation. All of these mutations cause the production of an abnormally short, nonfunctional MSH6 protein or a partially active version of the protein. When the MSH6 protein is absent or working inadequately the number of mistakes that are left unrepaired during cell division increases substantially.
If the cells continue to divide, errors accumulate in DNA; the cells become unable to function properly and may form a tumor in the colon or another part of the body - particularly the endometrium.
Link to Bethyl’s selection of DNA Damage/Repair antibodies.
Key tools for studying phosporylation events
By Tom Vendelbo: 10.01.07 in Drug discovery research
Phospho-specific antibodies are the new key tools for studying phosphorylation events.
Quote from Bethyl Laboratories product update for December:
X-ray repair cross-complementing gene I protein (XRCC1) in complex with DNA polymerase beta, DNA ligase III, and poly(ADP-ribose) polymerase is important in the base excision repair process.
Anti-Phospho XRCC1 (S485/T488) is only one of over 60 antibodies Bethyl Laboratories offers in their portfolio of polyclonal antibodies to phosphorylated proteins.
Phospho-specific antibodies have emerged as key tools for studying phosphorylation events. These antibodies are directed specifically against phosphorylated proteins. The key attribute is that they do not recognize the unphosphorylated form of the protein.
See the complete list of phospho-specific antibodies.
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By Sms-gruppen.dk: 3.01.07 in Immunology, Microbiology
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